Reproductive function in young Swedish men - Time trend, prenatal and adult exposure to smoking and phthalates

Jonatan Axelsson

Reproductive function in young Swedish men - Time trend, prenatal and adult exposure to smoking and phthalates

Jonatan Axelsson

Reproduktionsmedicin, Malmö

Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

214 Nedladdningar (Pure)

Sammanfattning

Popular Abstract in Swedish
Det har diskuterats huruvida mäns spermiekoncentration minskat och missbildningar i pojkars könsorgan ökat under den senare delen av 1900-talet. Med säkerhet har dock testikelcancer ökat flerfaldigt under samma tidsperiod.
Målet med denna avhandling var dels att undersöka huruvida skånska mäns spermakvalitet hade förändrats under det förra årtiondet, dels att studera samband mellan olika miljöfaktorer och manlig reproduktionsfunktion. Dessa miljöfaktorer var exponering för egen rökning, föräldrarnas rökning under graviditeten, samt för ftalater (en sorts plastmjukgörare) både under fostertiden och i vuxenlivet.
Vi rekryterade 314 unga män mellan år 2008 och 2010, främst från Pliktverket i Kristianstad i samband med mönstringen, och i viss utsträckning också män från gymnasieskolor i Malmö-Lund-området. Männen fick besvara frågor om föräldrarnas rökning under graviditeten. Uppgifter om moderns rökning inhämtades även från Socialstyrelsens födelseregister.
Vi hade tillgång till blodprov från 112 av männens mödrar, tagna under graviditeten. Dessa prov hade tagits vid en screening för röda hund, varefter proven sparats i en biobank. I dessa prov, liksom i urin- och blodprov från männen själva, mättes nedbrytningsprodukter (metaboliter) av ftalater som markörer för exponering.
De rekryterade männens spermakvalitet jämfördes med den hos män rekryterade på ett liknande sätt år 2000 till 2001. Därefter studerades samband mellan exponering för både rökning och ftalater såväl under fostertiden som i vuxenlivet, och männens reproduktionsfunktion.
Vi fann inte någon förändring i spermakvaliteten under det senaste årtiondet.
Däremot hade de män vars fäder eller mödrar rökt under graviditeten ett påtagligt lägre spermieantal. Vidare tycktes exponering under fostertiden för de två ftalaterna di-isononylftalat (DiNP) och dietylhexylftalat (DEHP) ha samband med en sänkt testikelvolym respektive spermavolym. Slutligen hade exponering för DEHP och dibutylftalat (DBP) i vuxenlivet samband med en lägre andel framåtrörliga spermier, vilket kan tänkas påverka fertiliteten.
Således verkade både exponering föräldrarnas rökning under graviditeten och för ftalater under fostertiden samt i vuxenlivet, ha samband med en sänkt manlig reproduktionsfunktion.

Originalspråk	engelska
Kvalifikation	Doktor
Tilldelande institution	Institutionen för translationell medicin
Handledare	Giwercman, Aleksander, handledare Rylander, Lars, handledare
Tilldelningsdatum	2015 maj 22
Förlag	Molecular Reproductive Medicine
ISBN (tryckt)	978-91-7619-124-8
Status	Published - 2015

Bibliografisk information

Defence details

Date: 2015-05-22
Time: 13:00
Place: Kvinnoklinikens aula, Plan 3, Jan Waldenströms gata 47, Skånes universitetssjukhus, Malmö

External reviewer(s)

Name: Sharpe, Richard
Title: Professor
Affiliation: Medical Research Council, University of Edinburgh, Storbrittanien

---

Ämnesklassifikation (UKÄ)

Klinisk medicin
Gynekologi, obstetrik och reproduktionsmedicin

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3 Artikel i vetenskaplig tidskrift

Prenatal phthalate exposure and reproductive function in young men.
Axelsson, J., Rylander, L., Rignell-Hydbom, A., Lindh, C., Jönsson, B. A. & Giwercman, A., 2015, I: Environmental Research. 138, s. 264-270
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review
The Impact of Paternal and Maternal Smoking on Semen Quality of Adolescent Men.
Axelsson, J., Rylander, L., Rignell-Hydbom, A., Silfver, K. Å., Stenqvist, A. & Giwercman, A., 2013, I: PLoS ONE. 8, 6, e66766.
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Fil
1098 Nedladdningar (Pure)
No secular trend over the last decade in sperm counts among Swedish men from the general population.
Axelsson, J., Rylander, L., Rignell-Hydbom, A. & Giwercman, A., 2011, I: Human Reproduction. 26, s. 1012-1016
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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@phdthesis{8d0ce4e8c93741cd932ee0432d3afedb,

title = "Reproductive function in young Swedish men - Time trend, prenatal and adult exposure to smoking and phthalates",

abstract = "A decrease in male reproductive function, including sperm counts, during the second half of the 20th century, has been postulated. During this period, testicular cancer has increased several-fold. Environmental and lifestyle-related factors have been proposed as explanations for a possible negative trend in male reproductive function. One important lifestyle factor is smoking. However, smoking during pregnancy appears to play a greater role for a man's reproductive function than smoking by the man himself. As regards environmental chemicals, one type of compound to which humans are exposed is phthalates. These are often used as plasticizers in different consumer products. Several phthalates have been reported as decreasing male reproductive function in laboratory animals, especially when given during the foetal period. Between 2008 and 2010, 314 men from the general Swedish population were recruited. Their semen quality was compared with a group of men recruited in a similar manner between 2000 and 2001. The participants also delivered serum and urinary samples and answered questionnaires concerning maternal and paternal smoking during pregnancy. Data on maternal smoking was additionally assessed through the Swedish Medical Birth Register. Through a Swedish screening program for rubella, maternal serum samples were retrieved from the men's prenatal period. We analysed metabolites of phthalates as exposure markers both in the maternal sera and in urine and serum of the men. Associations between parental smoking during pregnancy as well as phthalate metabolite levels, and parameters of male reproductive function were studied. In summary, we found no change in semen quality between 2000-2001 and 2008-2010. However, both maternal and paternal smoking during pregnancy were associated with reduced sperm counts in men whose other parent did not smoke. In addition, prenatal exposure to diethylhexyl phthalate (DEHP) and diisononyl phthalate (DiNP) appeared to be associated with decreased semen volume, and exposure to DiNP as well with smaller testicular size. Finally, adult exposure to DEHP and dibutyl phthalate (DBP) were associated with decreased progressive sperm motility, and DEHP exposure was also linked to a higher proportion of immature sperm. Thus, although no change in semen quality appeared to have occurred in Swedish men during the last decade, parental smoking and prenatal and adult exposure to certain phthalates may play a role in the male reproductive function.",

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N1 - Defence details Date: 2015-05-22 Time: 13:00 Place: Kvinnoklinikens aula, Plan 3, Jan Waldenströms gata 47, Skånes universitetssjukhus, Malmö External reviewer(s) Name: Sharpe, Richard Title: Professor Affiliation: Medical Research Council, University of Edinburgh, Storbrittanien ---

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N2 - A decrease in male reproductive function, including sperm counts, during the second half of the 20th century, has been postulated. During this period, testicular cancer has increased several-fold. Environmental and lifestyle-related factors have been proposed as explanations for a possible negative trend in male reproductive function. One important lifestyle factor is smoking. However, smoking during pregnancy appears to play a greater role for a man's reproductive function than smoking by the man himself. As regards environmental chemicals, one type of compound to which humans are exposed is phthalates. These are often used as plasticizers in different consumer products. Several phthalates have been reported as decreasing male reproductive function in laboratory animals, especially when given during the foetal period. Between 2008 and 2010, 314 men from the general Swedish population were recruited. Their semen quality was compared with a group of men recruited in a similar manner between 2000 and 2001. The participants also delivered serum and urinary samples and answered questionnaires concerning maternal and paternal smoking during pregnancy. Data on maternal smoking was additionally assessed through the Swedish Medical Birth Register. Through a Swedish screening program for rubella, maternal serum samples were retrieved from the men's prenatal period. We analysed metabolites of phthalates as exposure markers both in the maternal sera and in urine and serum of the men. Associations between parental smoking during pregnancy as well as phthalate metabolite levels, and parameters of male reproductive function were studied. In summary, we found no change in semen quality between 2000-2001 and 2008-2010. However, both maternal and paternal smoking during pregnancy were associated with reduced sperm counts in men whose other parent did not smoke. In addition, prenatal exposure to diethylhexyl phthalate (DEHP) and diisononyl phthalate (DiNP) appeared to be associated with decreased semen volume, and exposure to DiNP as well with smaller testicular size. Finally, adult exposure to DEHP and dibutyl phthalate (DBP) were associated with decreased progressive sperm motility, and DEHP exposure was also linked to a higher proportion of immature sperm. Thus, although no change in semen quality appeared to have occurred in Swedish men during the last decade, parental smoking and prenatal and adult exposure to certain phthalates may play a role in the male reproductive function.

AB - A decrease in male reproductive function, including sperm counts, during the second half of the 20th century, has been postulated. During this period, testicular cancer has increased several-fold. Environmental and lifestyle-related factors have been proposed as explanations for a possible negative trend in male reproductive function. One important lifestyle factor is smoking. However, smoking during pregnancy appears to play a greater role for a man's reproductive function than smoking by the man himself. As regards environmental chemicals, one type of compound to which humans are exposed is phthalates. These are often used as plasticizers in different consumer products. Several phthalates have been reported as decreasing male reproductive function in laboratory animals, especially when given during the foetal period. Between 2008 and 2010, 314 men from the general Swedish population were recruited. Their semen quality was compared with a group of men recruited in a similar manner between 2000 and 2001. The participants also delivered serum and urinary samples and answered questionnaires concerning maternal and paternal smoking during pregnancy. Data on maternal smoking was additionally assessed through the Swedish Medical Birth Register. Through a Swedish screening program for rubella, maternal serum samples were retrieved from the men's prenatal period. We analysed metabolites of phthalates as exposure markers both in the maternal sera and in urine and serum of the men. Associations between parental smoking during pregnancy as well as phthalate metabolite levels, and parameters of male reproductive function were studied. In summary, we found no change in semen quality between 2000-2001 and 2008-2010. However, both maternal and paternal smoking during pregnancy were associated with reduced sperm counts in men whose other parent did not smoke. In addition, prenatal exposure to diethylhexyl phthalate (DEHP) and diisononyl phthalate (DiNP) appeared to be associated with decreased semen volume, and exposure to DiNP as well with smaller testicular size. Finally, adult exposure to DEHP and dibutyl phthalate (DBP) were associated with decreased progressive sperm motility, and DEHP exposure was also linked to a higher proportion of immature sperm. Thus, although no change in semen quality appeared to have occurred in Swedish men during the last decade, parental smoking and prenatal and adult exposure to certain phthalates may play a role in the male reproductive function.

KW - Semen analysis

KW - maternal exposure

KW - paternal exposure

KW - smoking

KW - phthalate

M3 - Doctoral Thesis (compilation)

SN - 978-91-7619-124-8

T3 - Lund University Faculty of Medicine Doctoral Dissertation Series

PB - Molecular Reproductive Medicine

ER -

Reproductive function in young Swedish men - Time trend, prenatal and adult exposure to smoking and phthalates

Sammanfattning

Bibliografisk information

Ämnesklassifikation (UKÄ)

FN:s Globala mål

Tillgång till dokument

Fingeravtryck

Forskningsoutput

Prenatal phthalate exposure and reproductive function in young men.

The Impact of Paternal and Maternal Smoking on Semen Quality of Adolescent Men.

No secular trend over the last decade in sperm counts among Swedish men from the general population.

Citera det här