Revisiting the role of the mast cell in asthma.

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

Sammanfattning

In humans, mast cells are ubiquitously present in tissues adjacent to external environment and consequently have an important sentential role in host defence, homeostasis and repair. Their key role in allergen-mediated conditions has been recognized for many decades already. So far, therapies targeting mast cells offered clinical efficacy in allergic conditions except for asthma. More recently, sophisticated sampling and detection techniques revealed pleiotrophic immunological and functional properties of mast cells in and beyond asthma with potential clinical and management implications. These findings bring back the mast cell as a key player in the field of asthma and warrant a review of the recent literature.
Originalspråkengelska
Sidor (från-till)10-17
TidskriftCurrent Opinion in Pulmonary Medicine
Volym22
Nummer1
DOI
StatusPublished - 2016

Ämnesklassifikation (UKÄ)

  • Lungmedicin och allergi

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