Roles of TGF-β signals in tumor microenvironment via regulation of the formation and plasticity of vascular system

Tetsuro Watabe, Kazuki Takahashi, Kristian Pietras, Yasuhiro Yoshimatsu

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

Sammanfattning

Tumor cells evolve in tumor microenvironment composed of multiple cell types. Among these, endothelial cells (ECs) are the major players in tumor angiogenesis, which is a driver of tumor progression and metastasis. Increasing evidence suggests that ECs also contribute to tumor progression and metastasis as they modify their phenotypes to differentiate into mesenchymal cells through a process known as endothelial-mesenchymal transition (EndoMT). This plasticity of ECs is mediated by various cytokines, including transforming growth factor-β (TGF-β), and modulated by other stimuli depending on the cellular contexts. Recent lines of evidence have shown that EndoMT is involved in various steps of tumor progression, including tumor angiogenesis, intravasation and extravasation of cancer cells, formation of cancer-associated fibroblasts, and cancer therapy resistance. In this review, we summarize current updates on EndoMT, highlight the roles of EndoMT in tumor progression and metastasis, and underline targeting EndoMT as a potential therapeutic strategy.

Originalspråkengelska
Sidor (från-till)130-138
Antal sidor9
TidskriftSeminars in Cancer Biology
Volym92
DOI
StatusPublished - 2023

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi

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