Rules of engagement - Regulation of complement response in tissue

Anas Haider Abu-Humaidan

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

262 Nedladdningar (Pure)


Always in motion and probing for danger, complement proteins are found in every space and notch of the body. Their omnipresence combined with an ability to wreak havoc when activated, mandates a strong leash! The how, when, and where to unleash or constrain the complement response remain partly answered questions, despite the significant progress made in the field in the past 100 years.
The work in this thesis aims to answer some of these questions with models that compare healthy and disease states, using methods that investigate complement response in each. The investigation often followed the lines of
queries like: Is complement relevant to this disease state? Is complement activated or its expression induced? If so, through what mechanisms? And what local effect could the activation or induced expression have?
Chapter 1 provides an introduction to the complement system that tackles specific topics like complement’s discovery, evolution, function and role in disease. As well as challenges and progress made in complement targeted therapies. Chapter 2 discusses methods and models used in this thesis and in complement research in general. While chapter 3 focuses on the present investigation and where it falls within current knowledge about the local regulation of complement.
Tilldelande institution
  • Medicinska fakulteten
  • Sörensen, Ole, handledare
  • Schmidtchen, Artur, handledare
  • Egesten, Arne, handledare
Tilldelningsdatum2018 maj 31
ISBN (tryckt)978-91-7619-657-1
StatusPublished - 2018

Bibliografisk information

Defence details
Date: 2018-05-31
Time: 13:00
Place: Belfragesalen, BMC D15, Klinikgatan 32 i Lund
External reviewer(s)
Name: Molness, Tom Eirik
Title: professor
Affiliation: Faculty of Medicine, Oslo University
ISSN: 1652-8220
Lund University, Faculty of Medicine Doctoral Dissertation Series 2018:91

Ämnesklassifikation (UKÄ)

  • Medicin och hälsovetenskap


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