Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

Giacomo Canesin, Annalisa Di Ruscio, Mailin Li, Simone Ummarino, Andreas Hedblom, Reeham Choudhury, Agnieszka Krzyzanowska, Eva Csizmadia, Macarena Palominos, Anna Stiehm, Alexander Ebralidze, Shao Yong Chen, Mahmoud A. Bassal, Ping Zhao, Emanuela Tolosano, Laurence Hurley, Anders Bjartell, Daniel G. Tenen, Barbara Wegiel

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

4 !!Citations (SciVal)

Sammanfattning

Canesin et al. describe a role and mechanism for labile heme as a key player in regulating gene expression to promote carcinogenesis via binding to G-quadruplex in the c-MYC promoter. Hemopexin, a heme scavenger, may be used as a strategy to block progression of cancer.

Originalspråkengelska
Artikelnummer108181
TidskriftCell Reports
Volym32
Utgåva12
DOI
StatusPublished - 2020

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi

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