Secondhand Smoke Exposure Causes Bronchial Hyperreactivity via Transcriptionally Upregulated Endothelin and 5-hydroxytryptamine 2A Receptors.

Lei Cao, Yaping Zhang, Yong-Xiao Cao, Lars Edvinsson, Cang-Bao Xu

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

145 Nedladdningar (Pure)

Sammanfattning

Cigarette smoke exposure is strongly associated with airway hyperreactivity (AHR) which is the main characteristic seen in asthma. The intracellular MAPK signaling pathways are suggested to be associated with the airway damage to the AHR. In the present study, we hypothesize that secondhand cigarette smoke (SHS) exposure upregulates the bronchial contractile receptors via activation of the Raf/ERK/MAPK pathway.
Originalspråkengelska
Artikelnummere44170
TidskriftPLoS ONE
Volym7
Nummer8
DOI
StatusPublished - 2012

Ämnesklassifikation (UKÄ)

  • Annan klinisk medicin

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