Selective inhibition by simvastatin of IRF3 phosphorylation and TSLP production in dsRNA-challenged bronchial epithelial cells from COPD donors.

Biochemistry, Genetics and Molecular Biology

• Double-Stranded RNA 100%
• Simvastatin 100%
• Statin 18%

Pharmacology, Toxicology and Pharmaceutical Science

• Chronic Obstructive Lung Disease 100%
• Mevalonic Acid 30%
• Inflammation 20%
• Tumor Necrosis Factor 20%
• Drug Discovery 10%
• Anti-Inflammatory Drug 10%
• Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor 10%
• Statin (Protein) 10%

Immunology and Microbiology

• Viral Disease 20%
• Inflammation 20%
• Tumor Necrosis Factor 20%
• Dexamethasone 20%
• Epithelium 10%
• Transcription Factors 10%