TY - GEN
T1 - SENSITIVITY ANALYSIS OF THE ICRP BIOKINETIC MODEL PREDICTING THE ACTIVITY OF GD IN LUNGS AND 24-HOUR EXCRETION SAMPLES
AU - Ramljak, Belikse
AU - Malusek, Alexandr
AU - Eriksson Stenström, Kristina
AU - Rääf, Christopher
PY - 2023/11/11
Y1 - 2023/11/11
N2 - 148Gd may contribute to around 50% of the dose from inhalation in case of an accident at the European Spallation Source. Methods for its detection have been developed. They rely on biokinetic models predicting activities of the gamma emitters 146Gd (T1/2= 48.3 d) and 153Gd (T1/2= 240.4 d) as tracers in the lungs, urine, and faeces. The optimal choice of model parameters and associated uncertainties, which propagate to the estimates of the minimum detectable activity of 148Gd (T1/2= 84±4 y), have yet to be systematically investigated. This work presents a step in this direction. The authors have implemented the ICRP biokinetic model for Gd and performed a sensitivity analysis of the model to identify the most influential parameters. They will use this knowledge in subsequent uncertainty analysis and determination of the optimal measurement time window.
AB - 148Gd may contribute to around 50% of the dose from inhalation in case of an accident at the European Spallation Source. Methods for its detection have been developed. They rely on biokinetic models predicting activities of the gamma emitters 146Gd (T1/2= 48.3 d) and 153Gd (T1/2= 240.4 d) as tracers in the lungs, urine, and faeces. The optimal choice of model parameters and associated uncertainties, which propagate to the estimates of the minimum detectable activity of 148Gd (T1/2= 84±4 y), have yet to be systematically investigated. This work presents a step in this direction. The authors have implemented the ICRP biokinetic model for Gd and performed a sensitivity analysis of the model to identify the most influential parameters. They will use this knowledge in subsequent uncertainty analysis and determination of the optimal measurement time window.
KW - ESS
KW - radioactive aerosols
KW - internal dosimetry
UR - https://www.researchgate.net/publication/377388376_SENSITIVITY_ANALYSIS_OF_THE_ICRP_BIOKINETIC_MODEL_PREDICTING_THE_ACTIVITY_OF_GD_IN_LUNGS_AND_24-HOUR_EXCRETION_SAMPLES
M3 - Paper in conference proceeding
T3 - MEDICAL PHYSICS IN THE BALTIC STATES
SP - 55
EP - 59
BT - Kaunas University of Technology
PB - Kaunas University of Technology
ER -
