Standardization of the TRUE Test imidazolidinyl urea and diazolidinyl urea patches

T Agner, K E Andersen, B Björkner, Magnus Bruze, P J Frosch, B Gruvberger, U Hoeck, B Kreilgaard, T Menne, J Sommer

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

6 !!Citations (SciVal)

Sammanfattning

The preservatives imidazolidinyl urea (IMID, Germall 115) and diazolidinyl urea (DU, Germall II) are commonly used in cosmetic products and are well-known sensitizers. The aim of the present study was to establish the optimal patch test concentration in hydrophilic dried-in vehicle (TRUE Test) for IMID and DU. 181 patients were included in the study. Of these, 150 were patients referred for patch testing, 12 were patients with known allergy to IMID and 19 were patients with known allergy to DU. 76 consecutive patients and the 12 IMID-allergic patients were patch tested with a dilution series IMID (0 to 600 microg/cm(2)), formaldehyde (180 microg/cm(2)) and DU (200 microg/cm(2)). 74 consecutive patients and the 19 DU-allergic patients were patch tested with a dilution series of DU (0 to 600 microg/cm(2)), formaldehyde (180 microg/cm) and IMID (200 microg/cm(2)). A positive dose-response relationship was found. The number of doubtful reactions decreased with increasing test concentrations. No late reactions were observed. A patch test concentration in hydrophilic dried-in vehicle (TRUE Test) of 600 microg/cm(2) was found to be adequate and safe for both IMID and DU.
Originalspråkengelska
Sidor (från-till)21-25
TidskriftContact Dermatitis
Volym45
Utgåva1
DOI
StatusPublished - 2001

Ämnesklassifikation (UKÄ)

  • Dermatologi och venereologi

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