Synaptosomes (isolated nerve terminals) have been studied for more than 40 years. The preparation allows aspects of transmitter metabolism and release to be studied ex vivo from specific brain regions of animals of any age. Conditions can be devised to enable the terminals to fire spontaneous action potentials, allowing the presynaptic control of glutamate exocytosis to be studied. Recent developments have greatly increased the sensitivity with which the bioenergetics of the intra-synaptosomal mitochondria can be investigated.
|Titel på värdpublikation||Biochemical Society Transactions|
|Status||Published - 2010|
|Evenemang||Conference on Synaptopathies - Dysfunction of Synaptic Function - Newquay, England|
Varaktighet: 2009 sep. 2 → 2009 sep. 4
|Konferens||Conference on Synaptopathies - Dysfunction of Synaptic Function|
|Period||2009/09/02 → 2009/09/04|
Bibliografisk informationThe information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Neuronal Survival (013212041)
- Biokemi och molekylärbiologi