Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7

Sofia W. de Maré; Raminta Venskutonytė; Sandra Eltschkner; Bert L. de Groot; Karin Lindkvist-Petersson

doi:10.1016/j.str.2019.11.011

Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7

Sofia W. de Maré, Raminta Venskutonytė, Sandra Eltschkner, Bert L. de Groot, Karin Lindkvist-Petersson

Max Planck Institute for Biophysical Chemistry

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

AQP7 is an important glycerol channel in human adipocytes, and its dysfunction is linked to metabolic disorders. The high-resolution X-ray structures of AQP7 unravels the molecular details of how glycerol travels through the channel and provide a structural basis for development of small-molecule drugs for targeting AQP7.

Originalspråk	engelska
Sidor (från-till)	215-222.e3
Tidskrift	Structure
Volym	28
Nummer	2
DOI	https://doi.org/10.1016/j.str.2019.11.011
Status	Published - 2020 feb. 4

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10.1016/j.str.2019.11.011

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abstract = "AQP7 is an important glycerol channel in human adipocytes, and its dysfunction is linked to metabolic disorders. The high-resolution X-ray structures of AQP7 unravels the molecular details of how glycerol travels through the channel and provide a structural basis for development of small-molecule drugs for targeting AQP7.",

keywords = "adipocyte, AQP7, aquaglyceroporin, aquaporin 7, atomistic MD simulations, glycerol channel, water, X-ray structure",

author = "{de Mar{\'e}}, {Sofia W.} and Raminta Venskutonytė and Sandra Eltschkner and {de Groot}, {Bert L.} and Karin Lindkvist-Petersson",

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AU - de Groot, Bert L.

AU - Lindkvist-Petersson, Karin

PY - 2020/2/4

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KW - adipocyte

KW - AQP7

KW - aquaglyceroporin

KW - aquaporin 7

KW - atomistic MD simulations

KW - glycerol channel

KW - water

KW - X-ray structure

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Structural Basis for Glycerol Efflux and Selectivity of Human Aquaporin 7

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