Structural insights into eukaryotic aquaporin regulation

Susanna Törnroth-Horsefield, Kristina Hedfalk, Gerhard Fischer, Karin Lindkvist-Petersson, Richard Neutze

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

114 Citeringar (SciVal)

Sammanfattning

Aquaporin-mediated water transport across cellular membranes is an ancient, ubiquitous mechanism within cell biology. This family of integral membrane proteins includes both water selective pores (aquaporins) and transport facilitators of other small molecules such as glycerol and urea (aquaglyceroporins). Eukaryotic aquaporins are frequently regulated post-translationally by gating, whereby the rate of flux through the channel is controlled, or by trafficking, whereby aquaporins are shuttled from intracellular storage sites to the plasma membrane. A number of high-resolution X-ray structures of eukaryotic aquaporins have recently been reported and the new structural insights into gating and trafficking that emerged from these studies are described. Basic structural themes reoccur, illustrating how the problem of regulation in diverse biological contexts builds upon a limited set of possible solutions.

Originalspråkengelska
Sidor (från-till)2580-2588
Antal sidor9
TidskriftFEBS Letters
Volym584
Utgåva12
DOI
StatusPublished - 2010 juni
Externt publiceradJa

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