Studies of cadmium, mercury and lead in man. The value of X-ray fluorescence measurements in vivo

Jimmy Börjesson

Studies of cadmium, mercury and lead in man. The value of X-ray fluorescence measurements in vivo

Jimmy Börjesson

Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

Sammanfattning

Popular Abstract in Swedish
Bestämning av koncentrationen av kadmium, kvicksilver och bly i människokroppen. Värdet av röntgenfluorescensmätningar in vivo.

Originalspråk	engelska
Kvalifikation	Doktor
Tilldelande institution	Medicinsk strålningsfysik, Malmö
Handledare	[unknown], [unknown], handledare, Extern person
Tilldelningsdatum	1996 sep. 14
Förlag	Medical Radiation Physics, Lund University
ISBN (tryckt)	91-628-2140-7
Status	Published - 1996
Externt publicerad	Ja

Bibliografisk information

Defence details

Date: 1996-09-14
Time: 10:15
Place: Malmö University Hospital

External reviewer(s)

Name: Chettle, David R.
Title: Professor
Affiliation: McMaster Univ. Canada

---

Ämnesklassifikation (UKÄ)

Radiologi och bildbehandling

2 Artikel i vetenskaplig tidskrift

In vivo analysis of cadmium in battery workers versus measurements of blood, urine and work-place air
Börjesson, J., Bellander, T., Järup, L., Elinder, C. G. & Mattsson, S., 1997, I: Occupational and Environmental Medicine. 54, 6, s. 424-431
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review
In vivo XRF analysis of mercury: the relation between concentrations in the kidney and the urine
Börjesson, J., Barregård, L., Sällsten, G., Schütz, A., Jonson, R., Alpsten, M. & Mattsson, S., 1995, I: Physics in Medicine and Biology. 40, 3, s. 413-426
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Citera det här

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title = "Studies of cadmium, mercury and lead in man. The value of X-ray fluorescence measurements in vivo",

abstract = "Two XRF methods have been used for in vivo studies of mercury, cadmium and lead. Persons with a history of long-term occupational mercury exposure had elevated mercury concentrations in their kidneys (up to 65 µg/g). The minimum detectable concentration varied between 12 and 45 µg/g. Battery plant workers had elevated cadmium concentrations in their kidneys (up to 350 µg/g) and liver (up to 80 µg/g), with mean values about 3-5 times higher than the general population. The mean ratio between concentrations of cadmium in kidney and liver was 7. Levels in kidney and liver indicated that a simple integration of cadmium in work-place air is not sufficient to describe the body burden. Fingerbone lead in smelters was 6-8 times higher than in members of the general population. The half-time of bone lead in active workers was estimated to about 5 years during the accumulation phase. A model for description of a person{\textquoteright}s lead exposure in terms of lead in fingerbone, lead in blood and time of exposure has been developed and can be used, e.g. for retrospective blood lead estimates if the period of exposure and the current fingerbone lead is known. This will be of value for the evaluation of toxic effects of long-term lead exposure when data on previous lead levels are lacking. In total, in vivo measurements of mercury, cadmium and lead give unique information, which has shown to be an important tool for understanding of metal kinetics and toxicity. If the precision and accuracy of the method can be further improved, the technique will also have a given place in the clinical practice.",

keywords = "Physics, exposure assessment, smelter, half-time, fingerbone, occupational exposure, bone, thyroid, liver, kidney cortex, lead, mercury, cadmium, XRF, in vivo, Fysik, Chemistry, Kemi",

author = "Jimmy B{\"o}rjesson",

note = "Defence details Date: 1996-09-14 Time: 10:15 Place: Malm{\"o} University Hospital External reviewer(s) Name: Chettle, David R. Title: Professor Affiliation: McMaster Univ. Canada ---",

year = "1996",

language = "English",

isbn = "91-628-2140-7",

publisher = "Medical Radiation Physics, Lund University",

type = "Doctoral Thesis (compilation)",

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}

TY - THES

T1 - Studies of cadmium, mercury and lead in man. The value of X-ray fluorescence measurements in vivo

AU - Börjesson, Jimmy

N1 - Defence details Date: 1996-09-14 Time: 10:15 Place: Malmö University Hospital External reviewer(s) Name: Chettle, David R. Title: Professor Affiliation: McMaster Univ. Canada ---

PY - 1996

Y1 - 1996

N2 - Two XRF methods have been used for in vivo studies of mercury, cadmium and lead. Persons with a history of long-term occupational mercury exposure had elevated mercury concentrations in their kidneys (up to 65 µg/g). The minimum detectable concentration varied between 12 and 45 µg/g. Battery plant workers had elevated cadmium concentrations in their kidneys (up to 350 µg/g) and liver (up to 80 µg/g), with mean values about 3-5 times higher than the general population. The mean ratio between concentrations of cadmium in kidney and liver was 7. Levels in kidney and liver indicated that a simple integration of cadmium in work-place air is not sufficient to describe the body burden. Fingerbone lead in smelters was 6-8 times higher than in members of the general population. The half-time of bone lead in active workers was estimated to about 5 years during the accumulation phase. A model for description of a person’s lead exposure in terms of lead in fingerbone, lead in blood and time of exposure has been developed and can be used, e.g. for retrospective blood lead estimates if the period of exposure and the current fingerbone lead is known. This will be of value for the evaluation of toxic effects of long-term lead exposure when data on previous lead levels are lacking. In total, in vivo measurements of mercury, cadmium and lead give unique information, which has shown to be an important tool for understanding of metal kinetics and toxicity. If the precision and accuracy of the method can be further improved, the technique will also have a given place in the clinical practice.

AB - Two XRF methods have been used for in vivo studies of mercury, cadmium and lead. Persons with a history of long-term occupational mercury exposure had elevated mercury concentrations in their kidneys (up to 65 µg/g). The minimum detectable concentration varied between 12 and 45 µg/g. Battery plant workers had elevated cadmium concentrations in their kidneys (up to 350 µg/g) and liver (up to 80 µg/g), with mean values about 3-5 times higher than the general population. The mean ratio between concentrations of cadmium in kidney and liver was 7. Levels in kidney and liver indicated that a simple integration of cadmium in work-place air is not sufficient to describe the body burden. Fingerbone lead in smelters was 6-8 times higher than in members of the general population. The half-time of bone lead in active workers was estimated to about 5 years during the accumulation phase. A model for description of a person’s lead exposure in terms of lead in fingerbone, lead in blood and time of exposure has been developed and can be used, e.g. for retrospective blood lead estimates if the period of exposure and the current fingerbone lead is known. This will be of value for the evaluation of toxic effects of long-term lead exposure when data on previous lead levels are lacking. In total, in vivo measurements of mercury, cadmium and lead give unique information, which has shown to be an important tool for understanding of metal kinetics and toxicity. If the precision and accuracy of the method can be further improved, the technique will also have a given place in the clinical practice.

KW - Physics

KW - exposure assessment

KW - smelter

KW - half-time

KW - fingerbone

KW - occupational exposure

KW - bone

KW - thyroid

KW - liver

KW - kidney cortex

KW - lead

KW - mercury

KW - cadmium

KW - XRF

KW - in vivo

KW - Fysik

KW - Chemistry

KW - Kemi

M3 - Doctoral Thesis (compilation)

SN - 91-628-2140-7

PB - Medical Radiation Physics, Lund University

ER -

Studies of cadmium, mercury and lead in man. The value of X-ray fluorescence measurements in vivo

Sammanfattning

Bibliografisk information

Ämnesklassifikation (UKÄ)

Fingeravtryck

Forskningsoutput

In vivo analysis of cadmium in battery workers versus measurements of blood, urine and work-place air

In vivo XRF analysis of mercury: the relation between concentrations in the kidney and the urine

Citera det här