Studies on toll-like receptor stimuli responsiveness in HIV-1 and HIV-2 infections

Salma Nowroozalizadeh, Fredrik Månsson, Zacarias da Silva, Johanna Repits, Braima Dabo, Carla Pereira, Antonio Biague, Jan Albert, Jens Nielsen, Peter Aaby, Eva Maria Fenyö, Hans Norrgren, Birgitta G Holmgren, Marianne Jansson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Background: HIV-1 and HIV-2 are two related viruses with distinct clinical outcomes, where HIV-1 is more pathogenic and transmissible than HIV-2. The pathogenesis of both infections is influenced by the dysregulation and deterioration of the adaptive immune system. However, their effects on the responsiveness of innate immunity are less well known. Here, we report on toll-like receptor (TLR) stimuli responsiveness in HIV-1 or HIV-2 infections. Methods: Whole blood from 235 individuals living in Guinea-Bissau who were uninfected, infected with HIV-1, infected with HIV-2, and/or infected with HTLV-1, was stimulated with TLR7/8 and TLR9 agonists, R-848 and unmethylated CpG DNA. After TLR7/8 and TLR9 stimuli, the expression levels of IL-12 and IFN-alpha were related to gender, age, infection status, CD4(+) T cell counts. and plasma viral load. Results: Defective TLR9 responsiveness was observed in the advanced disease stage, along with CD4(+) T cell loss in both HIV-1 and HIV-2 infections. Moreover, TLR7/8 responsiveness was reduced in HIV-1 infected individuals compared with uninfected controls. Conclusions: Innate immunity responsiveness can be monitored by whole blood stimulation. Both advanced HIVA and HIV-2 infections may cause innate immunity dysregulation. (C) 2009 Elsevier Ltd. All rights reserved.
Originalspråkengelska
Sidor (från-till)325-331
TidskriftCytokine
Volym46
Nummer3
DOI
StatusPublished - 2009

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Division of Medical Microbiology (013250400), Infectious Diseases Research Unit (013242010), Division of Infection Medicine (SUS) (013008000)

Ämnesklassifikation (UKÄ)

  • Cell- och molekylärbiologi

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