Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis

Tatsuo Kobayashi, Yasuo Yoshihara, Atsuyoshi Samura, Harumoto Yamada, Masayuki Shinmei, Harald Roos, Stefan Lohmander

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

33 !!Citations (SciVal)
87 Nedladdningar (Pure)

Sammanfattning

OBJECTIVE: To explore in a cross sectional study in patients with primary knee osteoarthritis (OA) the relations between body mass index (BMI), disease stage, and the concentrations of a putative joint fluid marker of type II collagen synthesis, procollagen II C-propeptide.PATIENTS AND METHODS: The study included 142 patients with knee OA (median age 68, median BMI 24.1). OA was staged radiologically. The concentrations in synovial fluid of procollagen II C-propeptide were measured by a sandwich enzyme immunoassay.RESULTS: Joint fluid concentrations of procollagen II C-propeptide were increased in knees with OA (median 3.7 ng/ml), compared with published reference values for knees in healthy adult volunteers (median 1.3 ng/ml). The concentrations of procollagen II C-propeptide were independently related to both OA stage and BMI (rs = 0.343, p < 0.0001 and rs = 0.253, p = 0.002, respectively).CONCLUSIONS: Joint fluid concentrations of this putative marker of collagen II synthesis are high in early and mid-stage OA, but decrease in end stage disease. In addition and for the first time it was shown that the concentrations in synovial fluid of procollagen II C-propeptide increase with increasing BMI in primary knee OA. The increased joint fluid values of this marker in patients with primary knee OA and a high BMI, may reflect increased rates of collagen synthesis in their joint cartilage and could relate to the previously shown increased risk for disease progression in such patients.
Originalspråkengelska
Sidor (från-till)500-503
TidskriftAnnals of the Rheumatic Diseases
Volym56
Utgåva8
StatusPublished - 1997

Ämnesklassifikation (UKÄ)

  • Reumatologi och inflammation

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