Synthesis, characterization and antimalarial activity of new chromium arene-quinoline half sandwich complexes.

Lotta Glans, Dale Taylor, Carmen de Kock, Peter J Smith, Matti Haukka, John R Moss, Ebbe Nordlander

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

31 Citeringar (SciVal)

Sammanfattning

Organometallic analogs of chloroquine (CQ) are of interest as drug candidates that may be able to overcome the widespread chloroquine resistance developed by malaria parasites. Two new chromium arene CQ-analogs: [η(6)-N-(7-chloroquinolin-4-yl)-N'-(2-dimethylamino-methylbenzyl)-ethane-1,2-diamine]tricarbonylchromium 4 and [η(6)-N-(7-chloroquinolin-4-yl)-N'-(2-dimethylaminobenzyl)-ethane-1,2-diamine]tricarbonylchromium 9 have been synthesized and characterized. In addition, X-ray crystal structures of the intermediates (η(6)-benzyldimethylamine)tricarbonylchromium 2, [η(6)-2-((dimethylamino)methyl) benzaldehyde]tricarbonylchromium 3 and p-(η(6)-dimethylaminobenzaldehyde)tricarbonyl chromium 8 are reported. Compound 4 was more active than chloroquine against both CQ-sensitive and CQ-resistant strains of Plasmodium falciparum when antimalarial activity was tested in vitro. The activity of 4 against the CQ-resistant parasite strain was twice as high as for the organic ligand alone (IC(50) values of 33.9nM versus 63.1nM).
Originalspråkengelska
Sidor (från-till)985-990
TidskriftJournal of Inorganic Biochemistry
Volym105
Utgåva7
DOI
StatusPublished - 2011

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Chemical Physics (S) (011001060)

Ämnesklassifikation (UKÄ)

  • Biokemi och molekylärbiologi

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