Temporal development of the humoral immune response to surface antigens of Moraxella catarrhalis in young infants

Suzanne J. C. Verhaegh, Corne P. de Vogel, Kristian Riesbeck, Eric R. Lafontaine, Timothy F. Murphy, Henri A. Verbrugh, Vincent W. V. Jaddoe, Albert Hofman, Henriette A. Moll, Alex van Belkum, John P. Hays

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

17 Citeringar (SciVal)
113 Nedladdningar (Pure)

Sammanfattning

The primary Moraxella catarrha/is-specific humoral immune response, and its association with nasopharyngeal colonization, was studied in a cohort of infants from birth to 2 years of age. Results indicated that the levels of antigen-specific IgG, IgA and IgM showed extensive inter-individual variability over time, with IgM and IgA levels to all 9 recombinant domains, from 7 different OMPs, being relatively low throughout the study period. In contrast, the level of antigen-specific IgG was significantly higher for the recombinant domains Hag(385-863), MID764-913, MID962-1200, UspA1(557-704) and UspA2(165-318) in cord blood compared to 6 months of age (P <= 0.001). This was a most likely a consequence of maternal transmission of antigen-specific IgG to newborn babies, possibly indicating a future role for these 3 surface antigens in the development of an effective humoral immune response to M. catarrhalis. Finally, at 2 years of age, the levels of antigen-specific IgG still remained far below that obtained from cord blood samples, indicating that the immune response to M. catarrhalis has not matured at 2 years of age. We provide evidence that a humoral antibody response to OMPs UspA1,UspA2 and Hag/MID may play a role in the immune response to community acquired M. catarrhalis colonization events. (C) 2011 Elsevier Ltd. All rights reserved.
Originalspråkengelska
Sidor (från-till)5603-5610
TidskriftVaccine
Volym29
Utgåva34
DOI
StatusPublished - 2011

Ämnesklassifikation (UKÄ)

  • Mikrobiologi inom det medicinska området

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