Temporal Variation of Ljungan Virus Antibody Levels in Relation to Islet Autoantibodies and Possible Correlation to Childhood Type 1 Diabetes

Viral infection may trigger islet autoimmunity, type 1diabetes (T1D), or both. Fluctuating population density of
bank voles as a putative reservoir of Ljungan virus has been claimed to be associated with variations in T1D incidence
rate (IR). We tested the hypothesis that Ljungan virus antibodies reflecting prior exposure(s) to the virus may be
associated with islet autoimmunity, childhood diabetes or both. Incident, 0-18y, T1D patients (n = 63) were studied along
with age and sample time matched controls (n = 126). The younger children (< 9 years) tended to have a higher incidence
rate during winter (IR = 67.6, 95%CI 41.9-103.5) compared to summer (IR = 33.6, 95%CI 15.3-63.9) months. The
proportion of children with high level antibodies against Ljungan virus (LVAb) were both younger compared to the rest of
the children (p < 0.002) and correlated with half yearly T1D IR (r = 0.78, p = 0.005). High level LVAb fluctuating with
season and correlating with T1D IR indicates that past exposure to Ljungan virus may be associated with T1D.