The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.

Helena Fritz; Anna Gustafsson; Börje Ljungberg; Yvonne Ceder; Håkan Axelson; Björn Dahlbäck

doi:10.1371/journal.pone.0135991

The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.

Helena Fritz, Anna Gustafsson, Börje Ljungberg, Yvonne Ceder, Håkan Axelson, Björn Dahlbäck

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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Sammanfattning

High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.

Originalspråk	engelska
Artikelnummer	e0135991
Tidskrift	PLoS ONE
Volym	10
Nummer	8
DOI	https://doi.org/10.1371/journal.pone.0135991
Status	Published - 2015

Ämnesklassifikation (UKÄ)

Cancer och onkologi

FN:s Globala mål

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10.1371/journal.pone.0135991

plos_Fritz

http://www.ncbi.nlm.nih.gov/pubmed/26287733?dopt=Abstract

1 Doktorsavhandling (sammanläggning)

Axl RTK and microRNAs in urogenital cancers
Fritz, H., 2015, Translational Medicine. 218 s.
Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

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title = "The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.",

abstract = "High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.",

author = "Helena Fritz and Anna Gustafsson and B{\"o}rje Ljungberg and Yvonne Ceder and H{\aa}kan Axelson and Bj{\"o}rn Dahlb{\"a}ck",

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AU - Fritz, Helena

AU - Gustafsson, Anna

AU - Ljungberg, Börje

AU - Ceder, Yvonne

AU - Axelson, Håkan

AU - Dahlbäck, Björn

PY - 2015

Y1 - 2015

N2 - High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.

AB - High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.

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DO - 10.1371/journal.pone.0135991

M3 - Article

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JO - PLoS ONE

JF - PLoS ONE

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ER -

The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.

Sammanfattning

Ämnesklassifikation (UKÄ)

FN:s Globala mål

Tillgång till dokument

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Forskningsoutput

Axl RTK and microRNAs in urogenital cancers

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