The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.

Sidinh Luc, Tiago C Luis, Hanane Boukarabila, Iain C Macaulay, Natalija Buza-Vidas, Tiphaine Bouriez-Jones, Michael Lutteropp, Petter S Woll, Stephen J Loughran, Adam J Mead, Anne Hultquist, John Brown, Takuo Mizukami, Sahoko Matsuoka, Helen Ferry, Kristina Anderson, Sara Duarte, Deborah Atkinson, Shamit Soneji, Aniela DomanskiAlison Farley, Alejandra Sanjuan-Pla, Cintia Carella, Roger Patient, Marella de Bruijn, Tariq Enver, Claus Nerlov, Clare Blackburn, Isabelle Godin, Sten Eirik W Jacobsen

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. However, the commitment stage at which progenitors migrate from the bone marrow to the thymus remains unclear. Here we provide functional and molecular evidence at the single-cell level that the earliest progenitors in the neonatal thymus had combined granulocyte-monocyte, T lymphocyte and B lymphocyte lineage potential but not megakaryocyte-erythroid lineage potential. These potentials were identical to those of candidate thymus-seeding progenitors in the bone marrow, which were closely related at the molecular level. Our findings establish the distinct lineage-restriction stage at which the T cell lineage-commitment process transits from the bone marrow to the remote thymus.
Originalspråkengelska
Sidor (från-till)412-419
TidskriftNature Immunology
Volym13
Nummer4
DOI
StatusPublished - 2012

Ämnesklassifikation (UKÄ)

  • Cell- och molekylärbiologi

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