The Emerging Role of Topical Ocular Drugs to Target the Posterior Eye

Lixiang Wang, Mikael Ben Zhou, Hui Zhang

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

Sammanfattning

The prevalence of chronic fundus diseases is increasing with the aging of the general population. The treatment of these intraocular diseases relies on invasive drug delivery because of the globular structure and multiple barriers of the eye. Frequent intraocular injections bring heavy burdens to the medical care system and patients. The use of topical drugs to treat retinal diseases has always been an attractive solution. The fast development of new materials and technologies brings the possibility to develop innovative topical formulations. This article reviews anatomical and physiological barriers of the eye which affect the bioavailability of topical drugs. In addition, we summarize innovative topical formulations which enhance the permeability of drugs through the ocular surface and/or extend the drug retention time in the eye. This article also reviews the differences of eyes between different laboratory animals to address the translational challenges of preclinical models. The fast development of in vitro eye models may provide more tools to increase the clinical translationality of topical formulations for intraocular diseases. Clinical successes of topical formulations rely on continuous and collaborative efforts between different disciplines.

Originalspråkengelska
Sidor (från-till)465-494
Antal sidor30
TidskriftOphthalmology and Therapy
Volym10
Nummer3
DOI
StatusPublished - 2021

Ämnesklassifikation (UKÄ)

  • Farmaceutisk vetenskap
  • Oftalmologi

Fingeravtryck

Utforska forskningsämnen för ”The Emerging Role of Topical Ocular Drugs to Target the Posterior Eye”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här