The immune landscape of colorectal cancer

Artur Mezheyeuski, Patrick Micke, Alfonso Martín‐bernabé, Max Backman, Ina Hrynchyk, Klara Hammarström, Simon Ström, Joakim Ekström, Per Henrik Edqvist, Magnus Sundström, Fredrik Ponten, Karin Leandersson, Bengt Glimelius, Tobias Sjöblom

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

2 Citeringar (SciVal)

Sammanfattning

While the clinical importance of CD8+ and CD3+ cells in colorectal cancer (CRC) is well established, the impact of other immune cell subsets is less well described. We sought to provide a detailed overview of the immune landscape of CRC in the largest study to date in terms of patient numbers and in situ analyzed immune cell types. Tissue microarrays from 536 patients were stained using multiplexed immunofluorescence panels, and fifteen immune cell subclasses, representing adaptive and innate immunity, were analyzed. Overall, therapy‐naïve CRC patients clustered into an ‘inflamed’ and a ‘desert’ group. Most T cell subsets and M2 macrophages were enriched in the right colon (p‐values 0.046–0.004), while pDC cells were in the rectum (p = 0.008). Elderly patients had higher infiltration of M2 macrophages (p = 0.024). CD8+ cells were linked to improved survival in colon cancer stages I‐III (q = 0.014), while CD4+ cells had the strongest impact on overall survival in metastatic CRC (q = 0.031). Finally, we demonstrated repopulation of the immune infiltrate in rectal tumors post radiation, following an initial radiation‐induced depletion. This study provides a detailed analysis of the in situ immune landscape of CRC paving the way for better diagnostics and providing hints to better target the immune microenvironment.

Originalspråkengelska
Artikelnummer5545
TidskriftCancers
Volym13
Utgåva21
DOI
StatusPublished - 2021

Bibliografisk information

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi

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