The impact of diabetes mellitus on major amputation among patients with chronic limb threatening ischemia undergoing elective endovascular therapy- a nationwide propensity score adjusted analysis

Erika Lilja, Anders Gottsäter, Mervete Miftaraj, Jan Ekelund, Björn Eliasson, Ann Marie Svensson, Moncef Zarrouk, Peter Nilsson, Stefan Acosta

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Aim: To investigate the risk of major amputation after elective endovascular therapy in patients with chronic limb threatening ischemia (CLTI) comparing patients with and without diabetes mellitus (DM). Methods: In this nationwide cohort study, all patients registered in the Swedish Vascular Register after elective endovascular therapy for CLTI caused by infra-inguinal arterial disease from 2010 to 2014 were included. Among 4578 individuals, 2251 had DM and were registered in the National Diabetes Register between 2009 and 2014. A propensity score adjusted Cox regression analysis was conducted to compare outcomes between groups. Median follow-up was 4.0 and 3.6 years for patients with DM and without DM, respectively. Results: The incidence rates of major amputation and acute myocardial infarction (AMI) were 43% (95% CI 1.23–1.67) and 37% (95% CI 1.13–1.67) higher, respectively, among patients with DM compared to patients without DM. There was no difference in mortality (HR 1.04, 95% CI 0.95–1.14). Conclusions: Patients with DM had a higher risk of major amputation and AMI compared to those without DM after elective endovascular therapy for CLTI. Prevention of DM with CLTI is of utmost importance to reduce the risk of adverse limb and cardiovascular outcomes.

Originalspråkengelska
Artikelnummer107675
TidskriftJournal of Diabetes and its Complications
Volym35
Nummer2
Tidigt onlinedatum2020 juli 16
DOI
StatusPublished - 2021 feb.

Ämnesklassifikation (UKÄ)

  • Endokrinologi och diabetes

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