The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.

Anders Örbom; Sophie Eriksson; Erika Elgström; Tomas G Ohlsson; Rune Nilsson; Jan Tennvall; Sven-Erik Strand

doi:10.2967/jnumed.112.117028

The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.

Anders Örbom, Sophie Eriksson, Erika Elgström, Tomas G Ohlsson, Rune Nilsson, Jan Tennvall, Sven-Erik Strand

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

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Sammanfattning

The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribution. The aim of this study was to investigate the distribution of (177)Lu-DOTA-BR96 monoclonal antibodies targeting the Lewis Y antigen over 7 d using a syngeneic rat model of colon carcinoma.

Originalspråk	engelska
Sidor (från-till)	1404-1410
Tidskrift	Journal of Nuclear Medicine
Volym	54
Nummer	8
DOI	https://doi.org/10.2967/jnumed.112.117028
Status	Published - 2013

Ämnesklassifikation (UKÄ)

Radiologi och bildbehandling

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10.2967/jnumed.112.117028

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http://www.ncbi.nlm.nih.gov/pubmed/23804328?dopt=Abstract

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title = "The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.",

abstract = "The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribution. The aim of this study was to investigate the distribution of (177)Lu-DOTA-BR96 monoclonal antibodies targeting the Lewis Y antigen over 7 d using a syngeneic rat model of colon carcinoma.",

author = "Anders {\"O}rbom and Sophie Eriksson and Erika Elgstr{\"o}m and Ohlsson, {Tomas G} and Rune Nilsson and Jan Tennvall and Sven-Erik Strand",

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doi = "10.2967/jnumed.112.117028",

language = "English",

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The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model. / Örbom, Anders; Eriksson, Sophie; Elgström, Erika et al.
I: Journal of Nuclear Medicine, Vol. 54, Nr. 8, 2013, s. 1404-1410.

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

TY - JOUR

T1 - The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.

AU - Örbom, Anders

AU - Eriksson, Sophie

AU - Elgström, Erika

AU - Ohlsson, Tomas G

AU - Nilsson, Rune

AU - Tennvall, Jan

AU - Strand, Sven-Erik

PY - 2013

Y1 - 2013

N2 - The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribution. The aim of this study was to investigate the distribution of (177)Lu-DOTA-BR96 monoclonal antibodies targeting the Lewis Y antigen over 7 d using a syngeneic rat model of colon carcinoma.

AB - The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribution. The aim of this study was to investigate the distribution of (177)Lu-DOTA-BR96 monoclonal antibodies targeting the Lewis Y antigen over 7 d using a syngeneic rat model of colon carcinoma.

U2 - 10.2967/jnumed.112.117028

DO - 10.2967/jnumed.112.117028

M3 - Article

C2 - 23804328

SN - 0161-5505

VL - 54

SP - 1404

EP - 1410

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

IS - 8

ER -

The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.

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Ämnesklassifikation (UKÄ)

FN:s Globala mål

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