The Legionella pneumophila effector Lpg1137 is a homologue of mitochondrial SLC25 carrier proteins, not of known serine proteases

Marcin Gradowski, Krzysztof Pawlowski

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

1 Citering (SciVal)

Sammanfattning

Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results.

Originalspråkengelska
Artikelnummere3849
TidskriftPeerJ
Volym2017
Utgåva9
DOI
StatusPublished - 2017

Ämnesklassifikation (UKÄ)

  • Cell- och molekylärbiologi
  • Annan klinisk medicin

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