The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

Evald Rosengren; Pierre Åman; Sofia Thelin; Christer Hansson; Stefan Ahlfors; Peter Björk; Lars Jacobsson; Hans Rorsman

doi:10.1016/S0014-5793(97)01261-1

The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

Evald Rosengren, Pierre Åman, Sofia Thelin, Christer Hansson, Stefan Ahlfors, Peter Björk, Lars Jacobsson, Hans Rorsman

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.

Originalspråk	engelska
Sidor (från-till)	85-88
Tidskrift	FEBS Letters
Volym	417
Nummer	1
DOI	https://doi.org/10.1016/S0014-5793(97)01261-1
Status	Published - 1997

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Department of Dermatology and Venereology (Lund) (013006000), Department of Experimental Medical Science (013210000)

Ämnesklassifikation (UKÄ)

Biologi

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10.1016/S0014-5793(97)01261-1

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@article{51fc7f6378604422845b554d65d03607,

title = "The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase",

abstract = "A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.",

keywords = "Macrophage migration inhibitory factor, Phenylpyruvate tautomerase, Dopachrome tautomerase, Cytokine",

author = "Evald Rosengren and Pierre {\AA}man and Sofia Thelin and Christer Hansson and Stefan Ahlfors and Peter Bj{\"o}rk and Lars Jacobsson and Hans Rorsman",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Department of Dermatology and Venereology (Lund) (013006000), Department of Experimental Medical Science (013210000)",

year = "1997",

doi = "10.1016/S0014-5793(97)01261-1",

language = "English",

volume = "417",

pages = "85--88",

journal = "FEBS Letters",

issn = "1873-3468",

publisher = "Wiley-Blackwell",

number = "1",

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TY - JOUR

T1 - The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

AU - Rosengren, Evald

AU - Åman, Pierre

AU - Thelin, Sofia

AU - Hansson, Christer

AU - Ahlfors, Stefan

AU - Björk, Peter

AU - Jacobsson, Lars

AU - Rorsman, Hans

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Department of Dermatology and Venereology (Lund) (013006000), Department of Experimental Medical Science (013210000)

PY - 1997

Y1 - 1997

N2 - A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.

AB - A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.

KW - Macrophage migration inhibitory factor

KW - Phenylpyruvate tautomerase

KW - Dopachrome tautomerase

KW - Cytokine

U2 - 10.1016/S0014-5793(97)01261-1

DO - 10.1016/S0014-5793(97)01261-1

M3 - Article

SN - 1873-3468

VL - 417

SP - 85

EP - 88

JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

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