TY - JOUR
T1 - The stratum corneum barrier – From molecular scale to macroscopic properties
AU - Sparr, Emma
AU - Björklund, Sebastian
AU - Pham, Q. Dat
AU - Mojumdar, Enamul H.
AU - Stenqvist, B.
AU - Gunnarsson, M.
AU - Topgaard, D.
PY - 2023
Y1 - 2023
N2 - The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines mechanical strength with efficient barrier function. In this paper, we discuss these macroscopic properties of SC in relation to recent findings on molecular responses and structural diversity in SC protein and lipids. We put particular focus on the intermediate (colloidal) length scale and how the different SC substructures are organized with respect to each other, including effects of non-equilibrium conditions in the skin with respect to the gradients in water and other components.
AB - The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines mechanical strength with efficient barrier function. In this paper, we discuss these macroscopic properties of SC in relation to recent findings on molecular responses and structural diversity in SC protein and lipids. We put particular focus on the intermediate (colloidal) length scale and how the different SC substructures are organized with respect to each other, including effects of non-equilibrium conditions in the skin with respect to the gradients in water and other components.
KW - Fluid and solid lipids
KW - Heterogenous structures
KW - Keratin filaments
KW - Natural moisturizing factor
KW - Skin hydration
KW - Transport routes
U2 - 10.1016/j.cocis.2023.101725
DO - 10.1016/j.cocis.2023.101725
M3 - Review article
AN - SCOPUS:85167567586
SN - 1359-0294
VL - 67
JO - Current Opinion in Colloid and Interface Science
JF - Current Opinion in Colloid and Interface Science
M1 - 101725
ER -