The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival

Xiao Wang; A Charlotta Asplund; Anna Porwit; Jenny Flygare; C I Edvard Smith; Birger Christensson; Birgitta Sander

doi:10.1111/j.1365-2141.2008.07329.x

The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival

Xiao Wang, A Charlotta Asplund, Anna Porwit, Jenny Flygare, C I Edvard Smith, Birger Christensson, Birgitta Sander

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL.

Originalspråk	engelska
Sidor (från-till)	248-52
Tidskrift	British Journal of Haematology
Volym	143
Nummer	2
DOI	https://doi.org/10.1111/j.1365-2141.2008.07329.x
Status	Published - 2008 okt.
Externt publicerad	Ja

Ämnesklassifikation (UKÄ)

Hematologi

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10.1111/j.1365-2141.2008.07329.xLicens: Ospecificerad

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title = "The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival",

abstract = "Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL.",

keywords = "Aged, Aged, 80 and over, Biomarkers, Tumor/analysis, Cell Nucleus/chemistry, Cyclin D1/genetics, Cytoplasm/chemistry, Female, Gene Expression, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, Kaplan-Meier Estimate, Lymphoma, Mantle-Cell/classification, Male, Middle Aged, SOXC Transcription Factors/genetics, Survival Rate",

author = "Xiao Wang and Asplund, {A Charlotta} and Anna Porwit and Jenny Flygare and Smith, {C I Edvard} and Birger Christensson and Birgitta Sander",

year = "2008",

month = oct,

doi = "10.1111/j.1365-2141.2008.07329.x",

language = "English",

volume = "143",

pages = "248--52",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley & Sons Inc.",

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TY - JOUR

T1 - The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma

T2 - correlation to overall survival

AU - Wang, Xiao

AU - Asplund, A Charlotta

AU - Porwit, Anna

AU - Flygare, Jenny

AU - Smith, C I Edvard

AU - Christensson, Birger

AU - Sander, Birgitta

PY - 2008/10

Y1 - 2008/10

N2 - Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL.

AB - Gene expression analysis demonstrated high expression of the neuronal transcription factor SOX11 in mantle cell lymphoma (MCL). In contrast to follicular lymphoma, small lymphocytic lymphoma and reactive lymphoid tissue, most MCLs tested (48/53 patients) expressed sox11 protein in the nucleus. Therefore nuclear sox11 expression represents a new tumour marker for a subset of MCL. However, 5/53 MCL cases expressed sox11 only in the cytoplasm; these MCL patients had a shorter survival compared to MCL with nuclear sox11 expression. These results suggest sox11 expression as a new diagnostic marker in MCL that could be related to the clinical and biological behaviour of MCL.

KW - Aged

KW - Aged, 80 and over

KW - Biomarkers, Tumor/analysis

KW - Cell Nucleus/chemistry

KW - Cyclin D1/genetics

KW - Cytoplasm/chemistry

KW - Female

KW - Gene Expression

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Immunohistochemistry

KW - Kaplan-Meier Estimate

KW - Lymphoma, Mantle-Cell/classification

KW - Male

KW - Middle Aged

KW - SOXC Transcription Factors/genetics

KW - Survival Rate

U2 - 10.1111/j.1365-2141.2008.07329.x

DO - 10.1111/j.1365-2141.2008.07329.x

M3 - Article

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SN - 0007-1048

VL - 143

SP - 248

EP - 252

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 2

ER -

The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival

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