Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area

Tongfei A Wang, Chin Fen Teo, Malin Åkerblom, Chao Chen, Marena Tynan-La Fontaine, Vanille Juliette Greiner, Aaron Diaz, Michael T McManus, Yuh Nung Jan, Lily Y Jan

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review


Body temperature control is essential for survival. In mammals, thermoregulation is mediated by the preoptic area of anterior hypothalamus (POA), with ∼30% of its neurons sensitive to brain temperature change. It is still unknown whether and how these temperature-sensitive neurons are involved in thermoregulation, because for eight decades they have only been identified via electrophysiological recording. By combining single-cell RNA-seq with whole-cell patch-clamp recordings, we identified Ptgds as a genetic marker for temperature-sensitive POA neurons. Then, we demonstrated these neurons' role in thermoregulation via chemogenetics. Given that Ptgds encodes the enzyme that synthesizes prostaglandin D2 (PGD2), we further explored its role in thermoregulation. Our study revealed that rising temperature of POA alters the activity of Ptgds-expressing neurons so as to increase PGD2 production. PGD2 activates its receptor DP1 and excites downstream neurons in the ventral medial preoptic area (vMPO) that mediates body temperature decrease, a negative feedback loop for thermoregulation.

Sidor (från-till)309-322.e7
StatusPublished - 2019 juli 17
Externt publiceradJa

Bibliografisk information

Copyright © 2019 Elsevier Inc. All rights reserved.

Ämnesklassifikation (UKÄ)

  • Neurovetenskaper


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