Tools for digital twins in continuous downstream processing

Simon Tallvod

Tools for digital twins in continuous downstream processing

Simon Tallvod

Avdelningen för kemiteknik

Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)

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Sammanfattning

Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. This change demands more advanced process control in the form of automation and digital tools such as digital twins, which in turn need adequate mathematical models and accessible process data.
This thesis discusses the concept of digital twins as well as the automation of modelling and data acquisition in integrated continuous downstream processes for the development and production of biopharmaceuticals. Utilizing in-house supervisory control software for chromatographic systems enables automation of modeling, calibration, sampling, and analysis in integrated downstream processes, advancing the development of digital twins.

Originalspråk	engelska
Kvalifikation	Doktor
Tilldelande institution	Avdelningen för kemiteknik
Handledare	Nilsson, Bernt, handledare Andersson, Niklas, Biträdande handledare
Tilldelningsdatum	2023 nov. 24
Utgivningsort	Lund
Förlag	Department of Chemical Engineering, Lund University
ISBN (tryckt)	978-91-7422-996-7
ISBN (elektroniskt)	978-91-7422-997-4
Status	Published - 2023 nov. 24

Bibliografisk information

Defence details
Date: 2023-11-24
Time: 09:00
Place: Lecture Hall DC:Stora hörsalen, IKDC, Sölvegatan 26, Faculty of Engineering LTH, Lund University, Lund
External reviewer(s)
Name: Dürauer, Astrid
Title: Priv.-Doz. Dipl.-Ing. Dr.
Affiliation: University of Natural Resources and Life Sciences (BOKU), Austria
---

Ämnesklassifikation (UKÄ)

Data- och informationsvetenskap (Datateknik)

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4 Artikel i vetenskaplig tidskrift
1 Kapitel samlingsverk

Automatic procedure for modelling, calibration, and optimization of a three-component chromatographic separation
Espinoza, D., Tallvod, S., Andersson, N. & Nilsson, B., 2024 apr. 12, I: Journal of Chromatography A. 1720, 11 s., 464805.
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Öppen tillgång
Methodology for fast development of digital solutions in integrated continuous downstream processing
Andersson, N., Fons, J. G., Isaksson, M., Tallvod, S., Espinoza, D., Sjökvist, L., Andersson, G. Z. & Nilsson, B., 2024, I: Biotechnology and Bioengineering. 121, 8, s. 2378-2387
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Öppen tillgång
Automated quality analysis in continuous downstream processes for small-scale applications
Tallvod, S., Espinoza, D., Gomis-Fons, J., Andersson, N. & Nilsson, B., 2023 aug. 2, I: Journal of chromatography. A. 1702, 10 s., 464085.
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Öppen tillgång

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title = "Tools for digital twins in continuous downstream processing",

abstract = "Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. This change demands more advanced process control in the form of automation and digital tools such as digital twins, which in turn need adequate mathematical models and accessible process data.This thesis discusses the concept of digital twins as well as the automation of modelling and data acquisition in integrated continuous downstream processes for the development and production of biopharmaceuticals. Utilizing in-house supervisory control software for chromatographic systems enables automation of modeling, calibration, sampling, and analysis in integrated downstream processes, advancing the development of digital twins.",

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N2 - Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. This change demands more advanced process control in the form of automation and digital tools such as digital twins, which in turn need adequate mathematical models and accessible process data.This thesis discusses the concept of digital twins as well as the automation of modelling and data acquisition in integrated continuous downstream processes for the development and production of biopharmaceuticals. Utilizing in-house supervisory control software for chromatographic systems enables automation of modeling, calibration, sampling, and analysis in integrated downstream processes, advancing the development of digital twins.

AB - Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. This change demands more advanced process control in the form of automation and digital tools such as digital twins, which in turn need adequate mathematical models and accessible process data.This thesis discusses the concept of digital twins as well as the automation of modelling and data acquisition in integrated continuous downstream processes for the development and production of biopharmaceuticals. Utilizing in-house supervisory control software for chromatographic systems enables automation of modeling, calibration, sampling, and analysis in integrated downstream processes, advancing the development of digital twins.

KW - Digital twins

KW - Biopharmaceuticals

KW - Downstream processing

KW - Chromatography

KW - Mathematical modeling

KW - Ion exchange

KW - Automation

KW - Sampling

KW - Model calibration

KW - Python

M3 - Doctoral Thesis (compilation)

SN - 978-91-7422-996-7

PB - Department of Chemical Engineering, Lund University

CY - Lund

ER -

Tools for digital twins in continuous downstream processing

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Bibliografisk information

Ämnesklassifikation (UKÄ)

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Forskningsoutput

Automatic procedure for modelling, calibration, and optimization of a three-component chromatographic separation

Methodology for fast development of digital solutions in integrated continuous downstream processing

Automated quality analysis in continuous downstream processes for small-scale applications

Citera det här