Towards engineered yeast as production platform for capsaicinoids

Nina Muratovska, Paulo Silva, Tatiana Pozdniakova, Humberto Pereira, Carl Grey, Björn Johansson, Magnus Carlquist

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review


Capsaicinoids are bioactive alkaloids produced by the chili pepper fruit and are known to be the most potent agonists of the human pain receptor TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). They are currently produced by extraction from chili pepper fruit or by chemical synthesis. Transfer of the biosynthetic route to a microbial host could enable more efficient capsaicinoid production by fermentation and may also enable the use of synthetic biology to create a diversity of new compounds with potentially improved properties. This review summarises the current state of the art on the biosynthesis of capsaicinoid precursors in baker's yeast, Saccharomyces cerevisiae, and discusses bioengineering strategies for achieving total synthesis from sugar.
Antal sidor12
TidskriftBiotechnology Advances
StatusPublished - 2022

Ämnesklassifikation (UKÄ)

  • Industriell bioteknik
  • Mikrobiologi


Utforska forskningsämnen för ”Towards engineered yeast as production platform for capsaicinoids”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här