TY - JOUR
T1 - Traditional and Disease-Specific Risk Factors for Cardiovascular Events in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis
T2 - A Multinational Retrospective Study
AU - Moiseev, Sergey
AU - Bulanov, Nikolay
AU - Crnogorac, Matija
AU - Direskeneli, Haner
AU - Galesic, Kresimir
AU - Gazel, Ummugulsum
AU - Geetha, Duvuru
AU - Guillevin, Loic
AU - Hruškova, Zdenka
AU - Little, Mark A.
AU - O'Neill, Liam
AU - Makarov, Egor
AU - McAdoo, Stephen P.
AU - Mohammad, Aladdin J.
AU - Moran, Sarah
AU - Novikov, Pavel
AU - Pusey, Charles D.
AU - Rahmattulla, Chinar
AU - Satrapova, Veronika
AU - Silva, Joana
AU - Suvorov, Alexander
AU - Tesar, Vladimir
AU - Terrier, Benjamin
AU - Willeit, Peter
AU - Zhao, Ming Hui
AU - Kronbichler, Andreas
AU - Jayne, David R.W.
PY - 2023/9/29
Y1 - 2023/9/29
N2 - Objective. To investigate the occurrence of cardiovascular events (CVEs) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-Associated vasculitis (AAV) across the European Union, China, Turkey, Russia, the United Kingdom, and the USA. Methods. Patients with a definite diagnosis of AAV who were followed for ? 3 months and had sufficient documentation were included. Data on myocardial infarction (MI) and stroke were collected retrospectively from tertiary vasculitis centers. Univariate and multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results. Over a median follow-up of 62.0 months (IQR 22.6-100.0), CVEs (mostly MIs) occurred in 245 (10.7%) of 2286 patients with AAV, with a higher frequency in China and the UK. On multivariate regression analysis, older age (55-64.9 yrs, HR 2.93, 95% CI 1.99-4.31), smoking (HR 1.98, 95% CI 1.48-2.64), Chinese origin (HR 4.24, 95% CI 3.07-5.85), and pulmonary (HR 1.50, 95% CI 1.09-2.06) and kidney (HR 3.02, 95% CI 2.08-4.37) involvement were independent variables associated with a higher occurrence of CVEs. Conclusion. We showed that geographic region and both traditional and disease-specific (kidney involvement in particular) factors were independently associated with CVEs. Proper assessment and management of modifiable cardiovascular (CV) risk factors are essential for prevention of CV morbidity in patients with AAV.
AB - Objective. To investigate the occurrence of cardiovascular events (CVEs) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-Associated vasculitis (AAV) across the European Union, China, Turkey, Russia, the United Kingdom, and the USA. Methods. Patients with a definite diagnosis of AAV who were followed for ? 3 months and had sufficient documentation were included. Data on myocardial infarction (MI) and stroke were collected retrospectively from tertiary vasculitis centers. Univariate and multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs. Results. Over a median follow-up of 62.0 months (IQR 22.6-100.0), CVEs (mostly MIs) occurred in 245 (10.7%) of 2286 patients with AAV, with a higher frequency in China and the UK. On multivariate regression analysis, older age (55-64.9 yrs, HR 2.93, 95% CI 1.99-4.31), smoking (HR 1.98, 95% CI 1.48-2.64), Chinese origin (HR 4.24, 95% CI 3.07-5.85), and pulmonary (HR 1.50, 95% CI 1.09-2.06) and kidney (HR 3.02, 95% CI 2.08-4.37) involvement were independent variables associated with a higher occurrence of CVEs. Conclusion. We showed that geographic region and both traditional and disease-specific (kidney involvement in particular) factors were independently associated with CVEs. Proper assessment and management of modifiable cardiovascular (CV) risk factors are essential for prevention of CV morbidity in patients with AAV.
KW - ANCA-Associated vasculitis
KW - cardiovascular events
KW - myocardial infarction
KW - risk factors
KW - stroke
U2 - 10.3899/jrheum.220851
DO - 10.3899/jrheum.220851
M3 - Article
C2 - 36642436
AN - SCOPUS:85169523744
SN - 0315-162X
VL - 50
SP - 1145
EP - 1151
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 9
ER -