Treatment of cobalamin deficiency in dementia, evaluated clinically and with cerebral blood flow measurements

Karin Nilsson, Siegbert Warkentin, B Hultberg, Roger Fäldt, Lars Gustafson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

We investigated the relation between cobalamin deficiency, clinical changes and brain function in dementia patients. On admittance to the clinic, 24 patients had cobalamin deficiency, and dementia with additional symptoms of delirium. During cobalamin supplementation, the patients underwent repeated regional cerebral blood flow (rCBF) studies, psychiatric evaluations, and in some cases assessment with MMSE and the Organic Brain Syndrome scale. Fifteen patients who showed mild to moderate dementia improved clinically, and also showed a concomitant increase in their general CBF after treatment. In contrast, 9 patients who were severely demented showed no obvious clinical improvement, and no general blood flow change, although some regional flow increases were seen in sensory motor areas. We conclude that symptoms which probably indicated superimposed delirium such as clouding of consciousness, disorientation and clinical fluctuation, responded to the vitamin B12 supplementation, while the underlying dementia condition remained basically unchanged. The clinical improvement was also mirrored in general and focal rCBF changes.
Originalspråkengelska
Sidor (från-till)199-207
TidskriftAging
Volym12
Nummer3
StatusPublished - 2000

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Department of Psychogeriatrics (013304000), Department of Clinical Sciences, Lund (013230000)

Ämnesklassifikation (UKÄ)

  • Geriatrik
  • Psykiatri

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