Trend shifts in age-specific incidence for in situ and invasive cutaneous melanoma in sweden

Hanna Eriksson, Kari Nielsen, Ismini Vassilaki, Jan Lapins, Rasmus Mikiver, Johan Lyth, Karolin Isaksson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

Sammanfattning

Background: The incidence of invasive cutaneous melanoma (CM) is increasing in Sweden. The aim was to present age-and sex-specific trends of the age-standardised incidence and the average annual percentage change (AAPC) for in situ and invasive CM. Methods: Joinpoint regression models were used to analyse data from the Swedish Cancer Register and the Swedish Melanoma Registry 1997–2018 (N = 35,350 in situ CM; 59,932 CM). Results: The AAPC of CM for women was 4.5 (4.1–5.0; p < 0.001) for the period 1997–2018. For men, the APCC was 4.2 (3.0–5.4; p < 0.001), with a significantly higher annual percentage change (APC) for the period 2000–2018 (5.0; 4.6–5.4; p < 0.001) compared to 1997–1999. An increasing annual incidence of CM ≤ 0.6 mm and 0.7 mm Breslow tumour thickness was found for men with a significant incidence shift for the period 2006–2015, respectively. Similarly for women, with a significantly higher APC for CM ≤ 0.6 mm from 2005. The incidence of intermediate thick CM (2.1–4.0 mm) has not increased since 2011. The incidence of CM > 4.0 mm has been increasing among both sexes, with a significantly lower APC among women from 2005. Conclusions: The incidence of in situ and low-risk CM ≤ 1.0 mm in tumour thickness has been rising among both sexes since the 2000s.

Originalspråkengelska
Artikelnummer2838
TidskriftCancers
Volym13
Nummer11
DOI
StatusPublished - 2021 juni 1

Bibliografisk information

Funding Information:
The Swedish Cancer Society (190278Fk01H, 210406 JCIA), the Cancer Research Foundations of Radiumhemmet (181083), the Swedish Medical Society (SLS-934511, SLS-961466), the Swedish Society for Medical Research (2017), KI Funds (FS-2020:0007), Hudfonden (4-1880/2020), the Sigurd and Elsa Golje Memorial Fund (LA-2020-0148), Folkfonden (2020), Castenb?ck Fund (2020. K.I.: S. Paulsson Fund, M. Paulsson Fund K.N.: Hudfonden (2020), S.R. Gorthon foundation (2020), Krapperup foundation (0029-2020), FOU Region Skane (REGSKANE-815731) and ALF Lund University (2018?2020).

Funding Information:
Funding: H.E.: The Swedish Cancer Society (190278Fk01H, 210406 JCIA), the Cancer Research Foundations of Radiumhemmet (181083), the Swedish Medical Society (SLS-934511, SLS-961466), the Swedish Society for Medical Research (2017), KI Funds (FS-2020:0007), Hudfonden (4-1880/2020), the Sigurd and Elsa Golje Memorial Fund (LA-2020-0148), Folkfonden (2020), Castenbäck Fund (2020. K.I.: S. Paulsson Fund, M. Paulsson Fund K.N.: Hudfonden (2020), S.R. Gorthon foundation (2020), Krapperup foundation (0029-2020), FOU Region Skane (REGSKANE-815731) and ALF Lund University (2018–2020).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Ämnesklassifikation (UKÄ)

  • Dermatologi och venereologi
  • Cancer och onkologi

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