Tumors of the skin

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKapitel samlingsverkForskningPeer review

Sammanfattning

Skin cancer is the most common malignancy in humans. Clonal chromosome abnormalities have been reported in approximately 100 basal cell epitheliomas (BCC). In contrast to BCC, which has no recognized precursor lesion, squamous cell carcinoma (SCC) of the skin is known to develop through histologic stages, the most important of which are actinic keratosis (squamous cell dysplasia) and carcinoma in situ (severe dysplasia). A wide range of clinically and pathologically different benign and malignant melanocytic tumors are recognized. Appendageal tumors are subdivided into more than 30 benign and malignant subtypes showing apocrine and eccrine differentiation or follicular and sebaceous differentiation. Merkel cell carcinomas have near-diploid karyotypes, often showing rearrangements of chromosome 1. Dermal cylindromas may show similar genetic features to adenoid cystic carcinomas with the occurrence of a t (6; 9) (q22-23; p23-24) leading to a MYB-NFIB fusion gene.

Originalspråkengelska
Titel på värdpublikationCancer Cytogenetics
Undertitel på värdpublikationChromosomal and Molecular Genetic Aberrations of Tumor Cells
RedaktörerSverre Heim, Felix Mitelman
FörlagWiley-Blackwell
Sidor555-565
Antal sidor11
Utgåva4th
ISBN (elektroniskt)9781118795569
ISBN (tryckt)9781118795538
DOI
StatusPublished - 2015

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi
  • Medicinsk genetik

Fingeravtryck

Utforska forskningsämnen för ”Tumors of the skin”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här