Tumors with non-functional RB1 are killed by reduced gamma-tubulin levels.

Åsa Ehlén, Catalina Ana Rossello Castillo, Kristoffer von Stedingk, Greta Eklund, Elise Nilsson, Helen Pettersson, Karin Jirström, Maria Alvarado-Kristensson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

20 Citeringar (SciVal)

Sammanfattning

In various tumors inactivation of growth control is achieved by interfering with the RB1 signaling pathway. Here, we describe that RB1 and γ tubulin proteins moderate each other's expression by binding to their respective gene promoters. Simultaneous reduction of RB1 and γ tubulin protein levels result in an E2F1-dependent upregulation of apoptotic genes such as caspase 3. We report that in various tumors types, there is an inverse correlation between the expression levels of γ tubulin and RB1 and that in tumor cell lines with a non-functioning RB1, reduction of γ tubulin protein levels leads to induction of apoptosis. Thus, the RB1/γ tubulin signal network can be considered as a new target for cancer treatment.
Originalspråkengelska
Sidor (från-till)17241-17247
TidskriftJournal of Biological Chemistry
Volym287
Utgåva21
DOI
StatusPublished - 2012

Bibliografisk information

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pathology (Malmö) (013031000), Pathology, (Lund) (013030000), Molecular Medicine (013031200), Molecular Tumour Biology (013017540)

Ämnesklassifikation (UKÄ)

  • Cell- och molekylärbiologi

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