Ubiquitous Structural Signaling in Bacterial Phytochromes.

Alexander Björling, Oskar Berntsson, Heikki Takala, Kevin D Gallagher, Hardik Patel, Emil Gustavsson, Rachael St Peter, Phu Duong, Angela Nugent, Fan Zhang, Peter Berntsen, Roberto Appio, Ivan Rajkovic, Heli Lehtivuori, Matthijs R Panman, Maria Hoernke, Stephan Niebling, Rajiv Harimoorthy, Tilman Lamparter, Emina A StojkovićJanne A Ihalainen, Sebastian Westenhoff

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

18 Citeringar (SciVal)

Sammanfattning

The phytochrome family of light-switchable proteins has long been studied by biochemical, spectroscopic and crystallographic means, while a direct probe for global conformational signal propagation has been lacking. Using solution X-ray scattering, we find that the photosensory cores of several bacterial phytochromes undergo similar large-scale structural changes upon red-light excitation. The data establish that phytochromes with ordinary and inverted photocycles share a structural signaling mechanism and that a particular conserved histidine, previously proposed to be involved in signal propagation, in fact tunes photoresponse.
Originalspråkengelska
Sidor (från-till)3379-3383
TidskriftThe Journal of Physical Chemistry Letters
Volym6
Utgåva17
DOI
StatusPublished - 2015

Ämnesklassifikation (UKÄ)

  • Biokemi och molekylärbiologi

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