Unraveling the brain's response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons

Ilse Eidhof; Daniel Twohig; Anna Falk

doi:10.1016/j.stem.2024.01.002

Unraveling the brain's response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons

Ilse Eidhof, Daniel Twohig, Anna Falk

Karolinska Institutet

Forskningsoutput: Tidskriftsbidrag › Debate/Note/Editorial › Peer review

Sammanfattning

COVID-19 patients often display dysfunctions of the nervous system, indicating an effect of SARS-CoV-2 on neural cells. Yang et al. now show that human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence. The study further identifies three FDA-approved drugs capable of reversing these cellular phenotypes.

Originalspråk	engelska
Sidor (från-till)	152-154
Antal sidor	3
Tidskrift	Cell Stem Cell
Volym	31
Nummer	2
DOI	https://doi.org/10.1016/j.stem.2024.01.002
Status	Published - 2024 feb. 1

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10.1016/j.stem.2024.01.002

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title = "Unraveling the brain's response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons",

abstract = "COVID-19 patients often display dysfunctions of the nervous system, indicating an effect of SARS-CoV-2 on neural cells. Yang et al. now show that human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence. The study further identifies three FDA-approved drugs capable of reversing these cellular phenotypes.",

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AB - COVID-19 patients often display dysfunctions of the nervous system, indicating an effect of SARS-CoV-2 on neural cells. Yang et al. now show that human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence. The study further identifies three FDA-approved drugs capable of reversing these cellular phenotypes.

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Unraveling the brain's response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons

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