Variation in the MC4R Gene Is Associated with Bone Phenotypes in Elderly Swedish Women.

Gaurav Garg, Jitender Kumar, Fiona McGuigan, Martin Ridderstråle, Paul Gerdhem, Holger Luthman, Kristina Åkesson

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

8 Citeringar (SciVal)
139 Nedladdningar (Pure)

Sammanfattning

Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk. Fat mass is a determinant of bone strength and both phenotypes have a strong genetic component. In this study, we examined the association between obesity associated polymorphisms (SNPs) with body composition, BMD, Ultrasound (QUS), fracture and biomarkers (Homocysteine (Hcy), folate, Vitamin D and Vitamin B12) for obesity and osteoporosis. Five common variants: rs17782313 and rs1770633 (melanocortin 4 receptor (MC4R); rs7566605 (insulin induced gene 2 (INSIG2); rs9939609 and rs1121980 (fat mass and obesity associated (FTO) were genotyped in 2 cohorts of Swedish women: PEAK-25 (age 25, n = 1061) and OPRA (age 75, n = 1044). Body mass index (BMI), total body fat and lean mass were strongly positively correlated with QUS and BMD in both cohorts (r(2) = 0.2-0.6). MC4R rs17782313 was associated with QUS in the OPRA cohort and individuals with the minor C-allele had higher values compared to T-allele homozygotes (TT vs. CT vs.
Originalspråkengelska
Artikelnummere88565
TidskriftPLoS ONE
Volym9
Utgåva2
DOI
StatusPublished - 2014

Ämnesklassifikation (UKÄ)

  • Näringslära
  • Medicinsk genetik
  • Ortopedi

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