Vitamin K and cancer

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskriftPeer review

23 Citeringar (SciVal)

Sammanfattning

Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions. This review discusses the effects of different vitamin K subspecies on tumour growth and the possible anti-tumour effects of increased vitamin K intake. Blocking carboxylation of vitamin K-dependent proteins with warfarin anticoagulation – what are the risks/benefits for carcinogenesis? Previous studies on both heparin and low molecular weight heparin blocking of the vitamin K-dependent factors X and II have shown tumour suppressive effects. Vitamin K has anti-inflammatory effects that could also impact carcinogenesis, but little data exists on this subject.

Originalspråkengelska
Sidor (från-till)555-567
TidskriftScandinavian Journal of Clinical and Laboratory Investigation
Volym77
Nummer8
Tidigt onlinedatum2017 sep. 21
DOI
StatusPublished - 2017

Ämnesklassifikation (UKÄ)

  • Cancer och onkologi

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