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Sammanfattning
Subclinical vitamin K deficits refer to carboxylation defects of different types of vitamin K-dependent hepatic and extrahepatic so-called Gla proteins without prolongation of the prothrombin time. This condition has been reported in different clinical situations due to insufficient supply or malabsorption of vitamin K as well as drug interactions. This review discusses the effects of different vitamin K subspecies on tumour growth and the possible anti-tumour effects of increased vitamin K intake. Blocking carboxylation of vitamin K-dependent proteins with warfarin anticoagulation – what are the risks/benefits for carcinogenesis? Previous studies on both heparin and low molecular weight heparin blocking of the vitamin K-dependent factors X and II have shown tumour suppressive effects. Vitamin K has anti-inflammatory effects that could also impact carcinogenesis, but little data exists on this subject.
Originalspråk | engelska |
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Sidor (från-till) | 555-567 |
Tidskrift | Scandinavian Journal of Clinical and Laboratory Investigation |
Volym | 77 |
Nummer | 8 |
Tidigt onlinedatum | 2017 sep. 21 |
DOI | |
Status | Published - 2017 |
Ämnesklassifikation (UKÄ)
- Cancer och onkologi
Fingeravtryck
Utforska forskningsämnen för ”Vitamin K and cancer”. Tillsammans bildar de ett unikt fingeravtryck.Projekt
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