Vitamin K2 (Menaquinone-7) Supplementation and its Effect on Glucose Tolerance Test in Healthy Volunteers

Type 2 diabetes can often be managed by healthier diet and exercise in early stages of the disease, but as it progresses oral medication is needed and later on the patients will require insulin to survive. Vitamin K is a fat soluble vitamin that is a cofactor in gamma-carboxylation and activation of coagulation proteins produced in the liver. There are also extrahepatic proteins named Gla proteins that require vitamin K to be activated. Previous studies suggest that some of these proteins have a connection to calcification of vessels, bone mineralization, metabolic syndrome and diabetes, but results are conflicting.