Walking by design: how to build artificial molecular motors made of proteins

Patrik F. Nilsson; Anna Zink; Olivier M.C. Laprévote; Chapin S. Korosec; Nils Gustafsson; Neil O. Robertson; Nancy R. Forde; Ralf Eichhorn; Birte Höcker; Paul M.G. Curmi; Heiner Linke

doi:10.1088/2399-1984/ad7d7e

Walking by design: how to build artificial molecular motors made of proteins

Patrik F. Nilsson, Anna Zink, Olivier M.C. Laprévote, Chapin S. Korosec, Nils Gustafsson, Neil O. Robertson, Nancy R. Forde, Ralf Eichhorn, Birte Höcker, Paul M.G. Curmi, Heiner Linke

Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift › Peer review

Sammanfattning

To design an artificial protein-based molecular motor that can autonomously step along a track is a key challenge of protein design and synthetic biology. We lay out a roadmap for how to achieve this aim, based on a modular approach that combines the use of natural, non-motor proteins with de novo design. We define what can be considered to constitute a successful artificial protein motor, identify key steps along the path to achieve these designs, and provide a vision for the future beyond this aim.

Originalspråk	engelska
Artikelnummer	042501
Tidskrift	Nano Futures
Volym	8
Nummer	4
DOI	https://doi.org/10.1088/2399-1984/ad7d7e
Status	Published - 2024 dec. 1

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© 2024 The Author(s). Published by IOP Publishing Ltd.

Ämnesklassifikation (UKÄ)

Den kondenserade materiens fysik (Här ingår: Materialfysik, nanofysik)

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10.1088/2399-1984/ad7d7e

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title = "Walking by design: how to build artificial molecular motors made of proteins",

abstract = "To design an artificial protein-based molecular motor that can autonomously step along a track is a key challenge of protein design and synthetic biology. We lay out a roadmap for how to achieve this aim, based on a modular approach that combines the use of natural, non-motor proteins with de novo design. We define what can be considered to constitute a successful artificial protein motor, identify key steps along the path to achieve these designs, and provide a vision for the future beyond this aim.",

keywords = "molecular motors, nanotechnology, protein design, proteins, synthetic biology",

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note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Published by IOP Publishing Ltd.",

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doi = "10.1088/2399-1984/ad7d7e",

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AU - Nilsson, Patrik F.

AU - Zink, Anna

AU - Laprévote, Olivier M.C.

AU - Korosec, Chapin S.

AU - Gustafsson, Nils

AU - Robertson, Neil O.

AU - Forde, Nancy R.

AU - Eichhorn, Ralf

AU - Höcker, Birte

AU - Curmi, Paul M.G.

AU - Linke, Heiner

PY - 2024/12/1

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N2 - To design an artificial protein-based molecular motor that can autonomously step along a track is a key challenge of protein design and synthetic biology. We lay out a roadmap for how to achieve this aim, based on a modular approach that combines the use of natural, non-motor proteins with de novo design. We define what can be considered to constitute a successful artificial protein motor, identify key steps along the path to achieve these designs, and provide a vision for the future beyond this aim.

AB - To design an artificial protein-based molecular motor that can autonomously step along a track is a key challenge of protein design and synthetic biology. We lay out a roadmap for how to achieve this aim, based on a modular approach that combines the use of natural, non-motor proteins with de novo design. We define what can be considered to constitute a successful artificial protein motor, identify key steps along the path to achieve these designs, and provide a vision for the future beyond this aim.

KW - molecular motors

KW - nanotechnology

KW - protein design

KW - proteins

KW - synthetic biology

UR - https://www.scopus.com/pages/publications/85206882043

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DO - 10.1088/2399-1984/ad7d7e

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SN - 2399-1984

VL - 8

JO - Nano Futures

JF - Nano Futures

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ER -

Walking by design: how to build artificial molecular motors made of proteins

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