Which Biomarkers Are Effective for Identifying Th2-Driven Inflammation in Asthma?

Zuzana Diamant, Ellen Tufvesson, Leif Bjermer

Forskningsoutput: TidskriftsbidragÖversiktsartikelPeer review

261 Nedladdningar (Pure)

Sammanfattning

Recognition of asthma as a heterogeneous disease revealed different potential molecular targets and urged the development of targeted, customized treatment modalities. Evidence was provided for different inflammatory subsets of asthma and more recently, further refined to T helper (Th)2-high and Th2-low subphenotypes with different responsiveness to standard and targeted pharmacotherapy. Given these differences in immunology and pathophysiology, proof of concept studies of novel treatment modalities for asthma should be performed in adequate, well-defined phenotypes. In this review, we describe both existing and novel biomarkers of Th2-inflammation in asthma that can be applied to classify asthma subphenotypes in clinical studies and for treatment monitoring.
Originalspråkengelska
Sidor (från-till)477-486
TidskriftCurrent Allergy and Asthma Reports
Volym13
Nummer5
DOI
StatusPublished - 2013

Ämnesklassifikation (UKÄ)

  • Lungmedicin och allergi

Fingeravtryck

Utforska forskningsämnen för ”Which Biomarkers Are Effective for Identifying Th2-Driven Inflammation in Asthma?”. Tillsammans bildar de ett unikt fingeravtryck.

Citera det här